Verena M. Dirsch
Univ.-Prof. Dr.
Vice-Head of
Pharmaceutical Sciences
University Professor
room 2G 452 (floor 4)
+43-1-4277-55270
- Molecular Targets Group
- Biomolecules for a Healthy Lifespan (PIs: Verena Dirsch and Karl-Heinz Wagner)
- 2022 - 2025
FWF – Project P35241
The Neolignan-derived Rexinoid LRK071 - 2016 - 2019
BMWFW: SINO AUSTRIA III
China: TCM-Research Cluster Austria III: Identification of natural products from Paridis rhizoma (Chonglou) as liver X receptor (LXR) and farnesoid X receptor (FXR) ligands.
https://oravm13.noc-science.at/apex/f?p=115:3:::NO::P3_PROJIDF,P3_PREVIOUS_PAGE:30706,5 - 2016 - 2017
Austria Wirtschaftsservice: PRIZE
Joint project between Universitiy of Vienna and Technical Universitiy Vienna
Synthetische Lignane als Proliferationshemmer bei Cardiovasculären Erkrankungen. - 2015 - 2018
Member of the research platform "Metabolomics School University of Vienna" (University of Vienna; Head: Wolfram Weckwerth)
Joint project between the Faculty of Life Sciences, Faculty of Chemistry, and the Faculty of Geoscience - 05/2016 - 04/2017
Austria Wirtschaftsservice GmbH (AWS)
Herstellungsverfahren für Leoligin-artige Lignane und deren Effekt auf das Wachstum von glatten Gefäßmuskelzellen - 2013 - 2015
FFG Bridge Project 841283
Establishing new models for the metabolic syndrome as screening platform for herbal drugs - 2012 - 2014
EU Contract No. PIIF-GA-2009-252881
TCM-VASC: Chinese Medicines used against Cardiovascular Disease.
http://cordis.europa.eu/project/rcn/106082_en.html - 2011 - 2017
Member of the Research platform “Active Aging” (University of Vienna; Head: Karl-Heinz Wagner)
Joint project between the Faculty of Life Sciences and the Center of Sport Sciences
http://www.univie.ac.at/antiox/projects_show.php?pr_id=15 - 2011 - 2014
FWF-NFN-Project S10704-B13 (Project Part PP04)
Drugs from nature targeting inflammatory.
www.uibk.ac.at/pharmazie/pharmakognosie/dnti - 2011 - 2014
FWF – Project P23317 (Co-PI; PI: Elke Heiss)
Antiproliferative and antimigratory activity of I3MO.
http://www.univie.ac.at/pharmakognosie/I3MO - 2011 - 2014
Project within the Graduate Program “Bioactivity Profiling & Metabolism” (University of Vienna)
Natural Products and their Impact on miRNAs in Activated Vascular Smooth Muscle Cells
http://biopromotion.univie.ac.at/projects/subproject-1/ - 2009 - 2012
EU Coordination action; no 223154
GP-TCM: Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era
http://www.gp-tcm.org/ - 2008 - 2011
FWF-NFN-Project S10704-B03
Drugs from nature targeting inflammatory.
www.uibk.ac.at/pharmazie/pharmakognosie/dnti - 2007 - 2010
Project within the Graduate Program "Molecular Drug Targets" (University of Vienna)
Virtual and Real screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase
http://www.mdpi.com/2218-0532/77/6/199 - 2006 - 2010
FWF-Project P18982-B17 Resveratrol and Shp2
http://pf.fwf.ac.at/de/wissenschaft-konkret/project-finder/4234 - 2006 - 2009
EU Contract No. LSHB-CT-2004-503467
Pro Kinase Research: Protein kinases and phosphatases as targets for new anti-atherogenic compounds.
www.proteinkinase-research.org/ - 2003 - 2006
DFG Sachbeihilfe VO 376/10-1/2 (Co-PI, PI: Angelika M. Vollmar, University of Munich)
Signaltransduction of apoptosis-induction by cephalostatin-1, isolated from a marine organism
www.cup.uni-muenchen.de/pb/aks/vollmar/ - 2001 - 2002
DPhG Foundation for Young Scientists T 197/01.003.00
Sesqiterpene lactones and apoptosis - 1994 - 1995
DFG-Fellowship DI 599/1-1
Postdoc at the Columbia University in New York
- 1984-1989
Studies of Pharmacy, University of Munich (LMU) - 1990
Approbation (approval as apothecary) - 1993
Graduation (Dr. rer.nat. summa cum laude ) University of Munich
(group of Prof. H Wagner; research field: phytochemistry) - 1994-1995
Postdoctoral fellow of the German Research Council (DFG) at the Department of Chemistry, Columbia University, New York, USA
(group of Prof. K Nakanishi; research field: natural product chemistry) - 1995-1998
Research associate at the Institute of Pharmacology, Toxicology and Pharmacy, of the Veterinarian School, University of Munich
(group of Prof. AM Vollmar; research field: pharmacology) - 1998-2004
Scientific assistant and from 2003 Lecturer (Privatdozentin) at the Department of Pharmacy, University of Munich
(group of Prof. AM Vollmar; research field: natural product pharmacology) - 2002/2003
State doctorate (Habilitation) and venia legendi for Pharmaceutical Biology as well as Pharmacology - 10/2004
Professor of Pharmacognosy at the Department of Pharmacognosy, University of Vienna - since 2005
Speaker of the Faculty Key Research Area „Drug Discovery from Nature” (2005-2021), from 2022: „Biomolecules for a Healthy Lifespan” (Faculty of Life Sciences, University of Vienna) - Since 2006
Head of the Department (since 03/2021: Division) of Pharmacognosy, University of Vienna - 2008-2014
Vice-Dean of the Faculty of Life Sciences, University of Vienna - 2009-2019
Deputy-member of the Senate, University of Vienna - 2014-2019
Deputy Speaker of the Center of Pharmaceutical Sciences, University of Vienna - 2020
Speaker of the Center of Pharmaceutical Sciences, University of Vienna - Since 03/2021
Vice-Head of the new Department of Pharmaceutical Sciences
- 1994
Postdoctoral Fellowship granted by the DFG (German Research Council) - 1997
Präventionspreis der Deutschen Herzhilfe 1997 - 1998
PHOENIX Pharmazie-Wissenschaftspreis (Pharmacology) - 2011
PHOENIX Pharmazie-Wissenschaftspreis (Pharmaceutical Biology) - 2011
KIWIE-Silver medal 2011– from the KWIA (Korean International Woman’s Invention Association)
ORCID iD: 0000-0002-9261-5293
Publications
Schwarz P, Perhal A, Schöberl LN, Kraus MM, Kirchmair J, Dirsch V. Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist. Biomedicines. 2022 Aug;10(9). doi: 10.3390/biomedicines10092076
Pferschy-Wenzig EM, Ortmann S, Atanasov AG, Hellauer K, Hartler J, Kunert O et al. Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling. Metabolites. 2022 Apr;12(4):288. doi: 10.3390/metabo12040288
Linder T, Papaplioura E, Ogurlu D, Geyrhofer S, Hummelbrunner S, Schachner D et al. Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents. Biomedicines. 2022 Jan;10(1):62. Epub 2021 Dec 28. doi: 10.3390/biomedicines10010062
Hou X, Malainer C, Atanasov AG, Heiß EH, Dirsch VM, Wang L et al. Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice. Journal of Natural Products. 2021 Dec 24;84(12):3110-3116. doi: 10.1021/acs.jnatprod.1c00881
Ladurner A, Schwarz P, Dirsch V. Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs). Natural Product Reports - NPR. 2021 Apr;38(4):757-781. Epub 2020 Oct 29. doi: 10.1039/D0NP00047G
Atanasov AG, Zotchev SB, Dirsch VM, the International Natural Product Sciences Taskforce, Supuran CT. Natural products in drug discovery: advances and opportunities. Nature Reviews Drug Discovery. 2021 Mar;20:200-216. Epub 2021 Jan 28. doi: 10.1038/s41573-020-00114-z
Blažević T, Reznicek G, Ding L, Yang G, Haiss P, Heiss EH et al. Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation. Frontiers in Pharmacology. 2021 Jan 21;11:609756. doi: 10.3389/fphar.2020.609756
Ladurner A, Linder T, Wang L, Hiebl V, Schuster D, Schnürch M et al. Characterization of a structural leoligin analog as farnesoid X receptor agonist and modulator of cholesterol transport. Planta Medica. 2020 Oct 1;86(15):1097-1107. doi: 10.1055/a-1171-8357
Dao-Huy T, Latkolik S, Bräuer J, Pfeil A, Stuppner H, Schnürch M et al. Structural features defining nf-κb inhibition by lignan-inspired benzofurans and benzothiophenes. Biomolecules. 2020 Aug;10(8):1131. doi: 10.3390/biom10081131
Wang D, Hiebl V, Schachner D, Ladurner A, Heiss EH, Atanasov AG et al. Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation. Biochemical Pharmacology. 2020 Jul;177:114022. doi: 10.1016/j.bcp.2020.114022
Zwirchmayr J, Grienke U, Hummelbrunner S, Seigner J, de Martin R, Dirsch VM et al. A biochemometric approach for the identification of in vitro anti-inflammatory constituents in masterwort. Biomolecules. 2020 May;10(5):679. doi: 10.3390/biom10050679
Resetar M, Liu X, Herdlinger S, Kunert O, Pferschy-Wenzig EM, Latkolik S et al. Polyacetylenes from Oplopanax horridus and Panax ginseng: Relationship between Structure and PPARγ Activation. Journal of Natural Products. 2020 Apr 24;83(4):918-926. doi: 10.1021/acs.jnatprod.9b00691
Hiebl V, Schachner D, Ladurner A, Heiss EH, Stangl H, Dirsch VM. Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations. Biological Procedures Online. 2020 Apr 11;22(1):7. doi: 10.1186/s12575-020-00120-w
Wang D, Hiebl V, Xu T, Ladurner A, Atanasov AG, Heiss EH et al. Impact of natural products on the cholesterol transporter ABCA1. Journal of Ethnopharmacology. 2020 Mar;249:112444. doi: 10.1016/j.jep.2019.112444
Linder T, Geyrhofer S, Papaplioura E, Wang L, Atanasov AG, Stuppner H et al. Design and synthesis of a compound library exploiting 5-methoxyleoligin as potential cholesterol efflux promoter. Molecules. 2020 Feb 4;25(3):662. doi: 10.3390/molecules25030662
Pan SP, Pirker T, Kunert O, Kretschmer N, Hummelbrunner S, Latkolik SL et al. C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling. Frontiers in Pharmacology. 2019 Nov 28;10:1351. doi: 10.3389/fphar.2019.01351
Joa H, Blažević T, Grojer C, Zeller I, Heiss EH, Atanasov AG et al. Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture. Phytomedicine. 2019 Jul;60:152938. doi: 10.1016/j.phymed.2019.152938
Linder T, Liu R, Atanasov AG, Li Y, Geyrhofer S, Schwaiger S et al. Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease. Chemical Science. 2019 May 14;10(22):5815-5820. doi: 10.1039/c9sc00446g
Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N et al. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Scientific Reports. 2018 Dec 1;8(1):11061. doi: 10.1038/s41598-018-29281-1
Hiebl V, Ladurner A, Latkolik S, Dirsch VM. Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR. Biotechnology Advances. 2018 Nov 1;36(6):1657-1698. doi: 10.1016/j.biotechadv.2018.03.003