Verena M. Dirsch
Univ.-Prof. Dr.
Vice-Head of
Pharmaceutical Sciences
University Professor
room 2G 452 (floor 4)
+43-1-4277-55270
- Molecular Targets Group
- Biomolecules for a Healthy Lifespan (PIs: Verena Dirsch and Karl-Heinz Wagner)
- 2022 - 2025
FWF – Project P35241
The Neolignan-derived Rexinoid LRK071 - 2016 - 2019
BMWFW: SINO AUSTRIA III
China: TCM-Research Cluster Austria III: Identification of natural products from Paridis rhizoma (Chonglou) as liver X receptor (LXR) and farnesoid X receptor (FXR) ligands.
https://oravm13.noc-science.at/apex/f?p=115:3:::NO::P3_PROJIDF,P3_PREVIOUS_PAGE:30706,5 - 2016 - 2017
Austria Wirtschaftsservice: PRIZE
Joint project between Universitiy of Vienna and Technical Universitiy Vienna
Synthetische Lignane als Proliferationshemmer bei Cardiovasculären Erkrankungen. - 2015 - 2018
Member of the research platform "Metabolomics School University of Vienna" (University of Vienna; Head: Wolfram Weckwerth)
Joint project between the Faculty of Life Sciences, Faculty of Chemistry, and the Faculty of Geoscience - 05/2016 - 04/2017
Austria Wirtschaftsservice GmbH (AWS)
Herstellungsverfahren für Leoligin-artige Lignane und deren Effekt auf das Wachstum von glatten Gefäßmuskelzellen - 2013 - 2015
FFG Bridge Project 841283
Establishing new models for the metabolic syndrome as screening platform for herbal drugs - 2012 - 2014
EU Contract No. PIIF-GA-2009-252881
TCM-VASC: Chinese Medicines used against Cardiovascular Disease.
http://cordis.europa.eu/project/rcn/106082_en.html - 2011 - 2017
Member of the Research platform “Active Aging” (University of Vienna; Head: Karl-Heinz Wagner)
Joint project between the Faculty of Life Sciences and the Center of Sport Sciences
http://www.univie.ac.at/antiox/projects_show.php?pr_id=15 - 2011 - 2014
FWF-NFN-Project S10704-B13 (Project Part PP04)
Drugs from nature targeting inflammatory.
www.uibk.ac.at/pharmazie/pharmakognosie/dnti - 2011 - 2014
FWF – Project P23317 (Co-PI; PI: Elke Heiss)
Antiproliferative and antimigratory activity of I3MO.
http://www.univie.ac.at/pharmakognosie/I3MO - 2011 - 2014
Project within the Graduate Program “Bioactivity Profiling & Metabolism” (University of Vienna)
Natural Products and their Impact on miRNAs in Activated Vascular Smooth Muscle Cells
http://biopromotion.univie.ac.at/projects/subproject-1/ - 2009 - 2012
EU Coordination action; no 223154
GP-TCM: Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era
http://www.gp-tcm.org/ - 2008 - 2011
FWF-NFN-Project S10704-B03
Drugs from nature targeting inflammatory.
www.uibk.ac.at/pharmazie/pharmakognosie/dnti - 2007 - 2010
Project within the Graduate Program "Molecular Drug Targets" (University of Vienna)
Virtual and Real screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase
http://www.mdpi.com/2218-0532/77/6/199 - 2006 - 2010
FWF-Project P18982-B17 Resveratrol and Shp2
http://pf.fwf.ac.at/de/wissenschaft-konkret/project-finder/4234 - 2006 - 2009
EU Contract No. LSHB-CT-2004-503467
Pro Kinase Research: Protein kinases and phosphatases as targets for new anti-atherogenic compounds.
www.proteinkinase-research.org/ - 2003 - 2006
DFG Sachbeihilfe VO 376/10-1/2 (Co-PI, PI: Angelika M. Vollmar, University of Munich)
Signaltransduction of apoptosis-induction by cephalostatin-1, isolated from a marine organism
www.cup.uni-muenchen.de/pb/aks/vollmar/ - 2001 - 2002
DPhG Foundation for Young Scientists T 197/01.003.00
Sesqiterpene lactones and apoptosis - 1994 - 1995
DFG-Fellowship DI 599/1-1
Postdoc at the Columbia University in New York
- 1984-1989
Studies of Pharmacy, University of Munich (LMU) - 1990
Approbation (approval as apothecary) - 1993
Graduation (Dr. rer.nat. summa cum laude ) University of Munich
(group of Prof. H Wagner; research field: phytochemistry) - 1994-1995
Postdoctoral fellow of the German Research Council (DFG) at the Department of Chemistry, Columbia University, New York, USA
(group of Prof. K Nakanishi; research field: natural product chemistry) - 1995-1998
Research associate at the Institute of Pharmacology, Toxicology and Pharmacy, of the Veterinarian School, University of Munich
(group of Prof. AM Vollmar; research field: pharmacology) - 1998-2004
Scientific assistant and from 2003 Lecturer (Privatdozentin) at the Department of Pharmacy, University of Munich
(group of Prof. AM Vollmar; research field: natural product pharmacology) - 2002/2003
State doctorate (Habilitation) and venia legendi for Pharmaceutical Biology as well as Pharmacology - 10/2004
Professor of Pharmacognosy at the Department of Pharmacognosy, University of Vienna - since 2005
Speaker of the Faculty Key Research Area „Drug Discovery from Nature” (2005-2021), from 2022: „Biomolecules for a Healthy Lifespan” (Faculty of Life Sciences, University of Vienna) - Since 2006
Head of the Department (since 03/2021: Division) of Pharmacognosy, University of Vienna - 2008-2014
Vice-Dean of the Faculty of Life Sciences, University of Vienna - 2009-2019
Deputy-member of the Senate, University of Vienna - 2014-2019
Deputy Speaker of the Center of Pharmaceutical Sciences, University of Vienna - 2020
Speaker of the Center of Pharmaceutical Sciences, University of Vienna - Since 03/2021
Vice-Head of the new Department of Pharmaceutical Sciences
- 1994
Postdoctoral Fellowship granted by the DFG (German Research Council) - 1997
Präventionspreis der Deutschen Herzhilfe 1997 - 1998
PHOENIX Pharmazie-Wissenschaftspreis (Pharmacology) - 2011
PHOENIX Pharmazie-Wissenschaftspreis (Pharmaceutical Biology) - 2011
KIWIE-Silver medal 2011– from the KWIA (Korean International Woman’s Invention Association)
ORCID iD: 0000-0002-9261-5293
Publications
Rycek L, Ticli V, Pyszkowski J, Latkolik S, Liu X, Atanasov AG et al. Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation. Journal of Natural Products. 2018 Nov;81(11):2419–2428. doi: 10.1021/acs.jnatprod.8b00439
Dreier D, Resetar M, Temml V, Rycek L, Kratena N, Schnürch M et al. Magnolol dimer-derived fragments as PPARγ-selective probes. Organic & Biomolecular Chemistry. 2018 Sept 20;16(38):7019-7028. doi: 10.1039/c8ob01745j
Waldbauer K, Seiringer G, Sykora C, Dirsch VM, Zehl M, Kopp B. Evaluation of Apricot, Bilberry, and Elderberry Pomace Constituents and Their Potential To Enhance the Endothelial Nitric Oxide Synthase (eNOS) Activity. ACS Omega. 2018 Sept;3(9):10545-10553. doi: 10.1021/acsomega.8b00638
Kirchweger B, Müller Kratz J, Ladurner A, Grienke U, Langer T, Dirsch V et al. In silico workflow for the discovery of natural products activating the G protein-coupled bile acid receptor 1. Frontiers in Chemistry. 2018 Jul 2;6:242. doi: 10.3389/fchem.2018.00242
Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH et al. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Molecular Nutrition and Food Research. 2018 Jul 1;62(14):1800011. doi: 10.1002/mnfr.201800011
Heiss EH, Waltenberger B, Schachner D, Jiang B, Krystof V, Liu W et al. Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor. Molecular Nutrition and Food Research. 2018 Apr 1;62(7):1700860. doi: 10.1002/mnfr.201700860
Holzner S, Brenner S, Atanasov AG, Senfter D, Stadler S, Nguyen CH et al. Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro. Food and Chemical Toxicology. 2018 Jan;111:114-124. doi: 10.1016/j.fct.2017.11.015
Nikzad-Langerodi R, Ortmann S, Pferschy-Wenzig EM, Bochkov V, Zhao YM, Miao JH et al. Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy. Talanta : the international journal of pure and applied analytical chemistry. 2017 Dec 1;175:264-272. doi: 10.1016/j.talanta.2017.07.045
Malainer C, Schachner D, Sangiovanni E, Atanasov AG, Schwaiger S, Stuppner H et al. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. Journal of Natural Products. 2017 Dec;80(12):3186-3193. doi: 10.1021/acs.jnatprod.7b00503
Dreier D, Latkolik S, Rycek L, Schnürch M, Dymáková A, Atanasov AG et al. Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation. Scientific Reports. 2017 Oct 20;7:13002. doi: 10.1038/s41598-017-12628-5
Liu X, Latkolik S, Atanasov AG, Kunert O, Pferschy-Wenzig EM, Heiss EH et al. Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors. Planta Medica: natural products and medicinal plant research. 2017 Oct;83(14-15):1242-1250. doi: 10.1055/s-0043-118226
Wang L, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H et al. The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability. Frontiers in Pharmacology. 2017 Sept 1;8(SEP):596. doi: 10.3389/fphar.2017.00596
Liu R, Heiss EH, Schachner D, Jiang B, Liu W, Breuss JM et al. Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo. Journal of Natural Products. 2017 Jul 28;80(7):2146–2150. Epub 2017 Jun 19. doi: 10.1021/acs.jnatprod.7b00268
Ladurner A, Zehl M, Grienke U, Hofstadler C, Faur N, Cardoso Pereira MDF et al. Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5. Frontiers in Pharmacology. 2017 Jul 17;8:468. doi: 10.3389/fphar.2017.00468
Wang L, Wesemann S, Krenn L, Ladurner A, Heiss EH, Dirsch VM et al. Erythrodiol, an olive oil constituent, increases the half-life of ABCA1 and enhances cholesterol efflux from THP-1-derived macrophages. Frontiers in Pharmacology. 2017 Jun 13;8:375. doi: 10.3389/fphar.2017.00375
Wang D, Tosevska A, Heiß EH, Ladurner A, Mölzer C, Wallner M et al. Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression. Journal of the American Heart Association. 2017 May;6(5):1-15. e005520. doi: 10.1161/JAHA.117.005520
Nguyen HC, Huttary N, Atanasov AG, Chatuphonprasert W, Brenner S, Fristiohady A et al. Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model. International Journal of Oncology. 2017 May;50(5):1879-1888. doi: 10.3892/ijo.2017.3956
Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D et al. Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. Molecular Nutrition & Food Research. 2017 Apr;61(4):1500960. Epub 2016 Nov 15. doi: 10.1002/mnfr.201500960
Nguyen HC, Brenner S, Huttary N, Atanasov AG, Dirsch VM, Chatuphonprasert W et al. AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis. Human Molecular Genetics. 2016 Nov 15;25(22):5006-5016. Epub 2016 Sept 27. doi: 10.1093/hmg/ddw329
Nguyen HC, Brenner S, Huttary N, Li Y, Atanasov AG, Dirsch VM et al. 12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply. Cancer Letters. 2016 Sept 28;380(1):174-183. doi: 10.1016/j.canlet.2016.06.022